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Forms: Conjugated Estrogens (Premarin) 0.625 mg tablets
Quantity: 14-336 pills
Type: Estrogens Conjugated brand, Premarin generic
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Conjugated Estrogens (CEs) or Conjugated Equine Estrogens (CEEs) - trade names include Premarin, Conjugase, Conpremin, Elrredin, Estroplus, Presomen 28, Primax, Six Din - is a hormonal medication from combination of estrogens pharmacological group. This medicine is indicated for menopausal hormone therapy in postmenopausal women who have had a hysterectomy for the treatment of moderate to severe vasomotor symptoms (hot flashes), vulvovaginal atrophy (atrophic vaginitis, atrophic urethritis), itching, burning, dryness of the vagina and surrounding areas; hypoestrogenism due to hypogonadism, ovariectomy, primary ovarian failure, abnormal uterine bleeding, for high-dose estrogen therapy of breast cancer in both women and men, prostate cancer in men, the prevention of postmenopausal osteoporosis.
Estrogens Conjugated are available in oral (tablets, caplets, dragees, capsules), intravenous injections, topical and local vaginal (cream, gel) pharmaceutical forms.
Related medications:
Pharmacological and medical categories:
ATC codes:
ICD-10 codes:
Indications and usage:
Premarin is a mixture of estrogens indicated for:
Dosage and administration:
Overdosage:
Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of Premarin therapy with institution of appropriate symptomatic care.
Dosage forms and strengths:
Premarin (Conjugated Estrogens) tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg.
Contraindications:
Warnings and precautions:
Adverse reactions, side effects:
Most common adverse reactions ( >= 5 percent) are: abdominal pain, asthenia, pain, back pain, headache, flatulence, depression, nausea, insomnia, breast pain, leucorrhea, endometrial hyperplasia, vaginal hemorrhage, and vaginitis.
To report suspected adverse reactions, contact Pfizer Inc. or your local FDA.
Drug interactions:
Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism.
Use in specific populations:
Nursing mothers
Estrogen administration has been shown to decrease the quantity and quality of breast milk.
Geriatric use
An increased risk of probable dementia in women over 65 years of age was reported in the Women's Health Initiative Memory ancillary studies of the Women's Health Initiative.
Patient counseling information:
Vaginal bleeding
Inform postmenopausal women of the importance of reporting vaginal bleeding to their healthcare provider as soon as possible.
Possible serious adverse reactions with estrogens
Inform postmenopausal women of possible serious adverse reactions of estrogen therapy including cardiovascular disorders, malignant neoplasms, and probable dementia.
Possible less serious but common adverse reactions with estrogens
Inform postmenopausal women of possible less serious but common adverse reactions of estrogen therapy such as headache, breast pain and tenderness, nausea and vomiting.
Pregnancy categories:
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
APIs used in medicine in combinations with conjugated estrogens:
Here is a list of popular medications containing conjugated estrogens as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
| Trade name of the drug | Pharmaceutical forms and doses | Companies |
| Conjugase | ||
| Premarin | ||
| Presomen 28 |
References:
Revised: March 2021