How and where to order Premarin (Estrogens Conjugated) 0.625 mg tablets online on Whole Lotta LIFE Foundation website:

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Forms: Conjugated Estrogens (Premarin) 0.625 mg tablets
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Type: Estrogens Conjugated brand, Premarin generic
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Conjugated Estrogens (CEs) or Conjugated Equine Estrogens (CEEs) - trade names include Premarin, Conjugase, Conpremin, Elrredin, Estroplus, Presomen 28, Primax, Six Din - is a hormonal medication from combination of estrogens pharmacological group. This medicine is indicated for menopausal hormone therapy in postmenopausal women who have had a hysterectomy for the treatment of moderate to severe vasomotor symptoms (hot flashes), vulvovaginal atrophy (atrophic vaginitis, atrophic urethritis), itching, burning, dryness of the vagina and surrounding areas; hypoestrogenism due to hypogonadism, ovariectomy, primary ovarian failure, abnormal uterine bleeding, for high-dose estrogen therapy of breast cancer in both women and men, prostate cancer in men, the prevention of postmenopausal osteoporosis.
Estrogens Conjugated are available in oral (tablets, caplets, dragees, capsules), intravenous injections, topical and local vaginal (cream, gel) pharmaceutical forms.


Premarin (Conjugated Estrogens) 0.625 mg tablets


Related medications:

  • Anastrozole (Arimidex)
  • Cabergoline (Dostinex)
  • Chlorotrianisene (Tace)
  • Clomiphene (Clomid)
  • Conjugated Estrogens, Medroxyprogesterone (Prempro, Premphase)
  • Conjugated Estrogens, Norgestrel (Prempak-C)
  • Cyproterone, Ethinyl Estradiol (Diane-35)
  • Desogestrel, Ethinyl Estradiol (Desogen)
  • Eflornithine (Vaniqa)
  • Estradiol (Estrace)
  • Estriol (Ovestin)
  • Estrone (Estragyn)
  • Ethinyl Estradiol (Ethinylestradiol)
  • Ethinyl Estradiol, Levonorgestrel (Alesse)
  • Exemestane (Aromasin)
  • Ibandronic Acid (Boniva)
  • Imatinib (Gleevec)
  • Letrozole (Femara)
  • Medroxyprogesterone (Cycrin)
  • Norethindrone (Aygestin, Norlutate)
  • Promestriene (Colpotrofin)
  • Tibolone (Tibofem)


    Pharmacological and medical categories:

  • Anti cancer medications
  • Combinations of estrogens
  • Estrogen receptors agonists
  • Hormonal drugs
  • Menopausal hormone therapy
  • Naturally occurring estrane steroids
  • Postmenopausal hormone therapy
  • Women's health


    ATC codes:

  • G - Genito urinary system and sex hormones
  • G03 - Sex hormones and modulators of the genital system
  • G03C - Estrogens
  • G03CA - Natural and semisynthetic estrogens, plain
  • G03CA57 - Conjugated Estrogens


    ICD-10 codes:

  • Malignant neoplasm of breast - C50
  • Malignant neoplasm of prostate - C61
  • Ovarian dysfunction - E28
  • Primary ovarian failure - E28.3
  • Other primary ovarian failure - E28.39
  • Testicular dysfunction - E29
  • Testicular hypofunction - E29.1
  • Pruritus - L29
  • Pruritus vulvae - L29.2
  • Osteoporosis without current pathological fracture - M81
  • Other noninflammatory disorders of vagina - N89
  • Other specified noninflammatory disorders of vagina - N89.8
  • Other abnormal uterine and vaginal bleeding - N93
  • Menopausal and other perimenopausal disorders - N95
  • Postmenopausal bleeding - N95.0
  • Menopausal and female climacteric states - N95.1
  • Postmenopausal atrophic vaginitis - N95.2
  • Other specified menopausal and perimenopausal disorders - N95.8
  • Unspecified menopausal and perimenopausal disorder - N95.9
  • Other skin changes - R23
  • Flushing - R23.2
  • Burn and corrosion of trunk - T21
  • Burn of unspecified degree of female genital region - T21.07
  • Encounter for prophylactic surgery - Z40
  • Encounter for prophylactic removal of ovary(s) - Z40.02
  • Long term (current) drug therapy - Z79
  • Hormone replacement therapy - Z79.890
  • Acquired absence of organs, not elsewhere classified - Z90
  • Acquired absence of both cervix and uterus - Z90.710
  • Acquired absence of ovaries, unilateral - Z90.721


    Indications and usage:

    Premarin is a mixture of estrogens indicated for:

  • Treatment of moderate to severe vasomotor symptoms due to menopause.
  • Treatment of moderate to severe vulvar and vaginal atrophy due to menopause.
  • Treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure.
  • Treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease.
  • Treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only).
  • Prevention of postmenopausal osteoporosis.


    Dosage and administration:

  • Daily administration of 0.3, 0.45, 0.625, 0.9, and 1.25 mg.
  • Cyclic administration of 0.3, 0.625, and 1.25 mg.


    Overdosage:

    Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of Premarin therapy with institution of appropriate symptomatic care.


    Dosage forms and strengths:

    Premarin (Conjugated Estrogens) tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg.


    Contraindications:

  • Undiagnosed abnormal genital bleeding.
  • Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic diseases.
  • Known or suspected estrogen-dependent neoplasia.
  • Active DVT, PE, or a history of these conditions.
  • Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions.
  • Known anaphylactic reaction or angioedema with Premarin.
  • Known liver impairment or disease.
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy.


    Warnings and precautions:

  • Estrogens increase the risk of gallbladder disease.
  • Discontinue estrogen if severe hypercalcemia, loss of vision, severe hypertriglyceridemia or cholestatic jaundice occurs.
  • Monitor thyroid function in women on thyroid replacement therapy.


    Adverse reactions, side effects:

    Most common adverse reactions ( >= 5 percent) are: abdominal pain, asthenia, pain, back pain, headache, flatulence, depression, nausea, insomnia, breast pain, leucorrhea, endometrial hyperplasia, vaginal hemorrhage, and vaginitis.

    To report suspected adverse reactions, contact Pfizer Inc. or your local FDA.


    Drug interactions:

    Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism.


    Use in specific populations:

    Nursing mothers

    Estrogen administration has been shown to decrease the quantity and quality of breast milk.

    Geriatric use

    An increased risk of probable dementia in women over 65 years of age was reported in the Women's Health Initiative Memory ancillary studies of the Women's Health Initiative.


    Patient counseling information:

    Vaginal bleeding

    Inform postmenopausal women of the importance of reporting vaginal bleeding to their healthcare provider as soon as possible.

    Possible serious adverse reactions with estrogens

    Inform postmenopausal women of possible serious adverse reactions of estrogen therapy including cardiovascular disorders, malignant neoplasms, and probable dementia.

    Possible less serious but common adverse reactions with estrogens

    Inform postmenopausal women of possible less serious but common adverse reactions of estrogen therapy such as headache, breast pain and tenderness, nausea and vomiting.


    Pregnancy categories:

  • D - Australia
  • X - United States (Should not be used during pregnancy)


    Salts and other forms:

  • Conjugated Estrogens Base
  • Conjugated Estrogens Mixture


    Synonyms, international and chemical names:

  • Conjugated Equine Estrogens (CEEs)
  • Conjugated Estrogens (CEs)
  • Estrogen berkonjugat
  • Estrogenes conjugues
  • Estrogens Conjugated Synthetic A
  • Estrogens Conjugated Synthetic B
  • Mixture of Estrogen Conjugates


    Brands, generics, trade names:

  • Conjugase - Elder Pharmaceuticals
  • Conpremin - Pfizer, Wyeth
  • Elrredin - Victory Enterprises
  • Estrin - Cipla
  • Estroplus - Solvay
  • Menostat - Medifarm Inversiones y Representaciones
  • Premarin - Pfizer
  • Presomen - Pfizer, Solvay, Wyeth
  • Presomen 28 - Pfizer
  • Primax - Elder Pharmaceuticals
  • Repogen - Libbs Farmaceutica
  • Six Din - Senosiain Laboratorios


    APIs used in medicine in combinations with conjugated estrogens:

  • Chlordiazepoxide
  • Diazepam
  • Fluphenazine
  • Medrogestone
  • Medroxyprogesterone
  • Meprobamate
  • Methyltestosterone
  • Norgestrel
  • Oxazepam
  • Vitamins


    Here is a list of popular medications containing conjugated estrogens as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Conjugase
  • Tablets, Sugar-Coated; Oral; Estrogens Conjugated 0.625 mg
  • Elder Pharmaceuticals
  • Premarin
  • Cream; Topical, Vaginal; Estrogens Conjugated 0.0625%
  • Injectable; Injection; Estrogens Conjugated 25 mg
  • Tablets; Oral; Estrogens Conjugated 0.3 mg
  • Tablets; Oral; Estrogens Conjugated 0.45 mg
  • Tablets; Oral; Estrogens Conjugated 0.625 mg
  • Tablets; Oral; Estrogens Conjugated 0.9 mg
  • Tablets; Oral; Estrogens Conjugated 1.25 mg
  • Tablets; Oral; Estrogens Conjugated 2.5 mg
  • Pfizer
  • IDS Group
  • Institute of Pharmaceutical Research and Technology
  • Metro Drug Distribution
  • Wyeth
  • Zuellig Pharma
  • Presomen 28
  • Tablets, Coated; Oral; Estrogens Conjugated 0.3 mg
  • Tablets, Coated; Oral; Estrogens Conjugated 0.6 mg
  • Tablets, Coated; Oral; Estrogens Conjugated 1.25 mg
  • Pfizer
  • Solvay
  • Wyeth



  • References:

  • Conjugated estrogens main article on Wikipedia: https://en.wikipedia.org/wiki/Conjugated_estrogens
  • Conjugated estrogens compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Conjugated-estrogens
  • Conjugated estrogens on DrugBank: https://go.drugbank.com/drugs/DB00286
  • Estrogen FAQ on MedlinePlus (revised 09/15/2017): https://medlineplus.gov/druginfo/meds/a682922.html
  • Estrogen Vaginal FAQ on MedlinePlus (revised 08/15/2018): https://medlineplus.gov/druginfo/meds/a606005.html
  • Estrogen Injection FAQ on MedlinePlus (revised 09/01/2010): https://medlineplus.gov/druginfo/meds/a606004.html
  • Premarin (Conjugated Estrogens) film-coated tablets drug label info on DailyMed (revised July 1, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Premarin (Conjugated Estrogens) vaginal cream drug label info on DailyMed (revised November 11, 2019): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Premarin (Conjugated Estrogens) lyophilized powder for injection solution drug label info on DailyMed (revised October 14, 2020): https://dailymed.nlm.nih.gov/dailymed/lookup...
  • Estrogens Conjugated for sale on Pharma Doctor: https://pharma-doctor.com/estrogens-conjugated.html
  • Estrogens Conjugated containing drugs on Drugs-About.com: https://drugs-about.com/ing/estrogens-conjugated.html
  • Premarin (Conjugated Estrogens) tablets official prescribing and patient information from the U.S. FDA (revised 06/2011): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Premarin (Conjugated Estrogens) vaginal cream official prescribing and patient information from the U.S. FDA (revised 11/2017): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Premarin (Conjugated Estrogens) film-coated tablets prescribing and patient information from Pfizer pharmaceutical company (revised 09/2018): http://labeling.pfizer.com/showlabeling.aspx?id=131
  • Premarin (Conjugated Estrogens) vaginal cream prescribing and patient information from from Pfizer pharmaceutical company (revised 09/2018): http://labeling.pfizer.com/showlabeling.aspx?id=132
  • Premarin (Conjugated Estrogens tablets, USP) official website: https://www.premarin.com/
  • Premarin (Conjugated Estrogens) vaginal cream official website: https://www.premarinvaginalcream.com/
  • Premarin (Conjugated Estrogens) tablets consumer medicine information from NPS MedicineWise (revised May 2020): https://www.nps.org.au/assets/medicines/...
  • Premarin (Conjugated Estrogens) 0.3 mg, 0.625 mg, 1.25 mg coated tablets patient information leaflet on Medicines.org.uk (revised 09/2020): https://www.medicines.org.uk/emc/files/pil.2900.pdf

    Revised: June 2021